Mexichem Fluor

Products

ZEPHEX®134a and ZEPHEX®227ea are low boiling, non-toxic and non-flammable hydrofluoroalkane (HFA) aerosol propellant gases. Both easily comply with the relevant industry toxicological specifications (IPACTl and ll). Whilst chemically quite similar, there are sufficient differences to give them physical properties that are complementary. If a formulation chemist has access to both, most MDI formulation challenges should be surmountable by choosing the appropriate HFA or blend thereof.

Generally the chemist should first attempt to achieve a successful formulation using ZEPHEX®134a alone. If this proves not to be possible the chemist should then consider using the higher priced ZEPHEX®227ea either alone or in blend.

The key differing properties of the two propellants are summarised below.

Property	ZEPHEX® 134a	ZEPHEX® 227ea	Comments
Density (Kg/m³ at 25°C)	1206.8	1387	Adjustment of liquid density valuable as a means of stabilising suspensions. Attempt to approach density of suspended solids. Use blending for fine tuning.
'Solvency'	'Polar' . Alcohol − like	'Less polar'. More CFC-like.	Description of the relative solvencies of these two HFAs, and how they can be further tuned, is complex. More information given in customer zone.
Boiling Point (°C)	-26.07	-16.45	Atomising power can be tuned by variation of the boiling point.

Basic information on both HFAs can be found in the Physical Properties section. More specialised information can be found in the Customer Zone, covering a wide range of topics including compatibilities, properties of mixtures and detailed solvent/non solvent discussion.

Services

Mexichem Fluor takes special and individual care of its customers, from the largest to the smallest, with a service and support package that is 'tailor made' to the requirements of the individual company. Utilising its vast background knowledge of all aspects of medical propellant supply, the world class service and support offered by Mexichem Fluor includes:

A US FDA inspected customer 'Acceptance Testing' service, which can independently analyse shipments before they are dispatched. Results are reported in a confidential manner directly to the customer.

Expert storage and transport engineering services meeting the requirements of all regions of the world especially the developing world and the tropics. Mexichem Fluor offers a unique depth of expertise and advice concerning the packages and containers used for the transport of material, the design and installation of bulk storage systems and the conversion of existing CFC storage tanks to HFA duty.

Analytical support for the validation and commissioning of storage facilities.
Tanks intended to store medical HFAs need to be commissioned and validated according to some special and precise requirements. Technical information, covering a wide range of topics relating to this is contained within the Customer Zone of this website.

A comprehensive regulatory support package for all countries.
Mexichem Fluor maintains a suite of regulatory support documentation for all of the major world markets including US Drug Master Files, their European equivalents and the more specialised requirements for some of the developing world countries.

Mexichem Fluor is always ready to assist in getting an experimental programme underway and can provide additional advice particularly relevant to early R&D work, and a substantial amount of propellant free of charge to any serious R&D programme.

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