Zephex® 134a

49211 - Zephex logo_Small

Relied upon by leading Metered Dose Inhaler (MDI) manufacturers for over twenty years, Zephex® 134a is by far the most widely used medical propellant in the world. Present in over 70% of MDIs it is used in nearly all the major high-volume formulations including salbutamol sulphate, beclomethasone diproprionate, ipratropium bromide, fluticasone and their numerous combinations.

Mexichem manufactures Zephex® 134a at dedicated facilities in the UK which are operated to cGMP standards. From the UK Zephex® 134a is then shipped globally to pharmaceutical customers in a fleet of dedicated isotanks and packages.

Zephex® 134a physical properties

Physical Property Units Data
Chemical Name 1,1,1,2-Tetrafluoroethane
Chemical Formula CF3CH2F
Molecular Weight 102.03
Boiling Point at 1 atm (1.013 bar) °C
°F
-26.09
-14.9
Melting Point °C
°F
-103.0
-153.4
Critical Temperature °C
°F
101.03
213.9
Critical Pressure bara
lb/in² abs
40.56
588.3
Critical Volume m³/kg
ft³/lb
1.97 x 10-³
0.0316
Critical Density kg/m³
lb/ft³
507.6
31.65
Liquid Density at 25°C(77°F) m³/kg
ft³/lb
1206.8
75.34
Vapour Density at 25°C(77°F) kg/m³
lb/ft³
52.34
3.264
Saturated Vapour Density at nBpt m³/kg
ft³/lb
5.26
0.328
Liquid Cp at 25°C(77°F) kJ/kg.K
Btu/lb·°F
1.43
0.344
Vapour Pressure at 25°C(77°F) bara 6.653
Latent Heat of Vaporisation at nBpt kJ/kg
Btu/lb
216.7
93.2
Liquid Thermal Conductivity at 25°C(77°F) W/m·K
Btu/hr·ft°F
0.0824
0.0476
Vapour Thermal Conductivity at
25°C(77°F) and 1 atm (1.013 bar)
W/m·K
Btu/hr·ft°F
0.0144
0.00836
Liquid Viscosity at 25°C(77°F) cP 0.199
Vapour Viscosity at
25°C(77°F) and 1 atm(1.013 bar)
cP 0.013
Coeficient of thermal expansion /°C 0.002766
Solubility of 134a in Water at 20°C
(68°F) and 1 atm (1.013 bar)
%w/w 0.0773
Solubility of Water in HFA-134a at
25°C(77°F) and 1 atm(1.013 bar)
%w/w 0.11
Flammability Limits in Air at 1 atm
(1.013 bar)
%v/v none
Autoignition Temperature °C
°F
770
1418
Liquid Dielectric Constant at 20°C 9.51
Vapour Dielectric Constant at
25°C(77°F) and 1 atm (1.013 bar)
1.014
Dielectric Strength (R12 = 1) 0.5
Dipole Moment D 2.06
Thermal Coductivity at 25 °C W/mK 0.082
Surface Tension at 25 °C mN/m 8.09
Toxicity AEL (8- and 12-hr TWA) ppm(v/v) 1000
TSCA Inventory Status Included
EINECS Inventory Status Included