Zephex® 134a
Relied upon by leading Metered Dose Inhaler (MDI) manufacturers for over twenty years, Zephex® 134a is by far the most widely used medical propellant in the world. Present in over 70% of MDIs it is used in nearly all the major high-volume formulations including salbutamol sulphate, beclomethasone diproprionate, ipratropium bromide, fluticasone and their numerous combinations.
Mexichem manufactures Zephex® 134a at dedicated facilities in the UK which are operated to cGMP standards. From the UK Zephex® 134a is then shipped globally to pharmaceutical customers in a fleet of dedicated isotanks and packages.
Zephex® 134a physical properties
| Physical Property | Units | Data |
|---|---|---|
| Chemical Name | - | 1,1,1,2-Tetrafluoroethane |
| Chemical Formula | - | CF3CH2F |
| Molecular Weight | - | 102.03 |
| Boiling Point at 1 atm (1.013 bar) | °C °F |
-26.09 -14.9 |
| Melting Point | °C °F |
-103.0 -153.4 |
| Critical Temperature | °C °F |
101.03 213.9 |
| Critical Pressure | bara lb/in² abs |
40.56 588.3 |
| Critical Volume | m³/kg ft³/lb |
1.97 x 10-³ 0.0316 |
| Critical Density | kg/m³ lb/ft³ |
507.6 31.65 |
| Liquid Density at 25°C(77°F) | m³/kg ft³/lb |
1206.8 75.34 |
| Vapour Density at 25°C(77°F) | kg/m³ lb/ft³ |
52.34 3.264 |
| Saturated Vapour Density at nBpt | m³/kg ft³/lb |
5.26 0.328 |
| Liquid Cp at 25°C(77°F) | kJ/kg.K Btu/lb·°F |
1.43 0.344 |
| Vapour Pressure at 25°C(77°F) | bara | 6.653 |
| Latent Heat of Vaporisation at nBpt | kJ/kg Btu/lb |
216.7 93.2 |
| Liquid Thermal Conductivity at 25°C(77°F) | W/m·K Btu/hr·ft°F |
0.0824 0.0476 |
| Vapour Thermal Conductivity at 25°C(77°F) and 1 atm (1.013 bar) |
W/m·K Btu/hr·ft°F |
0.0144 0.00836 |
| Liquid Viscosity at 25°C(77°F) | cP | 0.199 |
| Vapour Viscosity at 25°C(77°F) and 1 atm(1.013 bar) |
cP | 0.013 |
| Coeficient of thermal expansion | /°C | 0.002766 |
| Solubility of 134a in Water at 20°C (68°F) and 1 atm (1.013 bar) |
%w/w | 0.0773 |
| Solubility of Water in HFA-134a at 25°C(77°F) and 1 atm(1.013 bar) |
%w/w | 0.11 |
| Flammability Limits in Air at 1 atm (1.013 bar) |
%v/v | none |
| Autoignition Temperature | °C °F |
770 1418 |
| Liquid Dielectric Constant at 20°C | - | 9.51 |
| Vapour Dielectric Constant at 25°C(77°F) and 1 atm (1.013 bar) |
- | 1.014 |
| Dielectric Strength (R12 = 1) | - | 0.5 |
| Dipole Moment | D | 2.06 |
| Thermal Coductivity at 25 °C | W/mK | 0.082 |
| Surface Tension at 25 °C | mN/m | 8.09 |
| Toxicity AEL (8- and 12-hr TWA) | ppm(v/v) | 1000 |
| TSCA Inventory Status | - | Included |
| EINECS Inventory Status | - | Included |